WebNov 19, 2024 · Wnt–β-catenin signalling tightly controls embryogenesis, including hepatobiliary development, maturation and zonation. ... BIRC5 (encoding the antiapoptotic protein Survivin), NPM1, HDAC2 and ... WebThe enhancement of endogenous neurogenesis has been suggested in the treatment of traumatic brain injury (TBI); however, the factors that trigger the process of adult …

BIRC3 and BIRC5: multi‐faceted inhibitors in cancer

WebFeb 17, 2015 · BIRC5 was also reduced in the epithelial compartment (67.83% vs. 20.62%) (Figure 9, C and D); however, strong staining for BIRC5 in non-epithelial cell types in the … WebSurvivin and Wnt/β-catenin. Wnt/®-catenin signaling is implicated in the development of multiple cancers such as breast, colorectal, lung, prostate cancers and melanoma . During tumorigenesis, accumulation of β-catenin in the cytoplasm is recognized as the hallmark of the Wnt signaling pathway . rachel chicheportiche

Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic Strategies

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation … See more Survivin is a member of the IAP family of antiapoptotic proteins. It is shown to be conserved in function across evolution as homologues of the protein are found both in vertebrates and invertebrates. The first members of the … See more The single survivin gene can give rise to four different alternatively spliced transcripts: 1. Survivin, which has a three-intron–four-exon structure in both the mouse and human. 2. Survivin-2B, which has an insertion of an … See more p53 inhibits survivin expression at the transcriptional level Wild-type p53 has been shown to repress survivin expression at the mRNA level. Using an … See more Survivin has been shown to interact with: • Aurora B kinase, • CDCA8, • Caspase 3, See more A structural feature common to all IAP family proteins is that they all contain at least one baculoviral IAP repeat (BIR) domain characterized by a conserved zinc-coordinating … See more Apoptosis Apoptosis, the process of programmed cell death, involves complex signaling pathways and … See more Expression in cancer as a tool for cancer-directed therapy Survivin is known to be highly expressed in most tumour cell types and absent in normal cells, making it a good target for cancer therapy. The exploitation of survivin's over … See more WebMar 14, 2013 · Similarly to the Wnt protein palmitoyltransferase, porcupine (PPN) is essential to the activation of the Wnt/β‑catenin signaling pathway. However, little is known about the role of PPN activity in human gastric cancer, one of the most common causes of cancer-related mortality. Real‑time quantitative PCR was used to detect the expression … WebApr 23, 2024 · Background Baculoviral IAP repeat containing 5 (BIRC5) is overexpressed and plays as a key regulator in the progression of various human carcinomas. The … rachel chiger cadwalader